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L., Castangia, I., Zaru, M., Ncher, A., Diez-Sales, O., & Fadda, A

[01:09-02:46] And then the FDA stepped in and said, absolutely not

The Phase 2 dose-finding trial (N=338), published in the New England Journal of Medicine in 2023 (DOI: 10.1056/NEJMoa2301972), randomized participants with obesity (BMI 30-50) to retatrutide at doses ranging from 0.5mg to 12mg weekly or placebo over 48 weeks

Close collaboration with endocrinology is often ideal, especially for patients with complex medical histories. Barbieri said more studies are needed to determine how well GLP-1s work for HS and how best to use them moving forward